The physics of DNA and chromosomes /

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"Version: 20181001"--Title page verso.Includes bibliographical references (page 35).1. Introduction -- 2. Background -- A few definitions, the double helix, and chromatin -- The linking number -- Basics of genome organisation -- 3. Current directions -- All twisted up : supercoiling, transcription, and nucleosome assembly -- Packing it all up : the 3D spatial organisation of the nucleus -- 4. Outlook.Each of the tens of trillions of cells making up your body contains about two metres of DNA, which need to fit within the 10 microns container that is its nucleus--roughly a tenth of the diameter of a human hair. How is the DNA arranged in such a tight spot? A liver and a brain cell contain exactly the same genetic material, as they come from the same egg cell, yet they work very differently, because the patterns of genes that are on and off in the two is completely distinct. How is this at all possible? Biophysicists have found general principles that are beginning to answer these and similar questions. In this ebook we explore some of these principles, and describe a selection of topics where physicists have contributed to our current understanding of DNA and chromosomes.Final-year undergraduates, new PhD students and early-career scientists.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Davide Marenduzzo is professor of computational biophysics at the School of Physics and Astronomy at the University of Edinburgh, and currently a European Research Council fellow. His current interests include the biophysics of DNA, chromatin and chromosomes, but also cell motility, active matter and liquid crystal physics. Davide has coauthored about 200 articles on these and related topics in peer-reviewed journals, and he is author of a couple of popular physics articles in Physics World. Additionally, he coordinates outreach activities at the Higgs Centre for Theoretical Physics. Davide was awarded the 2010 IUPAP Young Scientist Prize in Statistical Physics 'for his contributions to the statistical mechanics of biomolecular and soft matter systems, in particular his groundbreaking simulations of DNA organization, of liquid crystals, and of active gels'.Title from PDF title page (viewed on November 8, 2018).

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

1 online resource (x, 35 pages) :illustrations (some color).

Language

English

ISBN/ISSN

9780750316026

Classification

572.8/6

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Media Type

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Carrier Type

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Edition

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Subject(s)

Biophysics.
SCIENCE / Life Sciences / Biophysics.
DNA
Chromosomes
DNA.
Chromosomes.

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Statement of Responsibility

Davide Marenduzzo.

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