Soft biological shells in bioengineering /

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Soft biological shells in bioengineering /

Miftahof, Roustem, - Personal Name; Institute of Physics (Great Britain), - Personal Name; Akhmadeev, Nariman R., - Personal Name;

"Version: 20190701"--Title page verso.Includes bibliographical references.9. Pharmacological modulations -- 9.1. Biological preliminaries -- 9.2. Modeling of competitive antagonist action -- 9.3. Modeling of allosteric interaction -- 9.4. Allosteric modulation of competitive agonist/antagonist action -- 9.5. Modeling of a PDE-5 inhibitorpart II. Applications. 10. The stomach -- 10.1. Anatomical considerations -- 10.2. Mechanical properties -- 10.3. Electromechanical phenomena -- 10.4. General model postulates -- 10.5. A functional unit -- 10.6. Co-transmission in the SIP-ganglion unit -- 10.7. The stomach as a soft biological shell -- 10.8. Gastric accommodation -- 10.9. The intrinsic regulatory system11. The small intestine -- 11.1. Anatomical and physiological considerations -- 11.2. General model postulates -- 11.3. Investigations into intestinal smooth muscle -- 11.4. The intestine as a soft biological shell -- 11.5. Pharmacology of intestinal motility12. The large intestine (colon) -- 12.1. Anatomical and physiological considerations -- 12.2. The colon as a soft biological shell -- 12.3. Pharmacology of colonic motility13. The gravid uterus -- 13.1. Anatomical considerations -- 13.2. A functional unit -- 13.3. Electrophysiological properties -- 13.4. Neuroendocrine modulators -- 13.5. Coupling phenomena -- 13.6. Crosstalk phenomena -- 13.7. Biological changes in the gravid uterus -- 13.8. Modeling of the gravid uterus -- 13.9. General model postulates -- 13.10. Investigations into the myometrium -- 13.11. Co-transmission in the myometrium -- 13.12. The gravid uterus as a soft biological shell -- 13.13. Investigations into the gravid human uterus14. The urinary bladder -- 14.1. Anatomical considerations -- 14.2. The detrusor -- 14.3. The neurohormonal regulatory system -- 14.4. Functional states in the bladder -- 14.5. Biomechanics of the detrusor -- 14.6. Models of the bladder -- 14.7. General model postulates -- 14.8. Investigations into the detrusor -- 14.9. Pharmacology of detrusor -- 14.10. The urinary bladder as a soft biological shell -- 14.11. Investigations into the urinary bladder -- 15. Conclusion.part I. Fundamentals of soft biological shells. 1. Geometry of the surface -- 1.1. Intrinsic geometry -- 1.2. Extrinsic geometry -- 1.3. Equations of Gauss and Codazzi -- 1.4. General curvilinear coordinates -- 1.5. Deformation of the surface -- 1.6. Equations of compatibility2. Parameterization of shells of complex geometry -- 2.1. Fictitious deformations -- 2.2. Parameterization of the equidistant surface -- 2.3. A single function variant of the method of fictitious deformation -- 2.4. Parameterization of a complex surface in preferred coordinates -- 2.5. Parameterization of complex surfaces on a plane3. Nonlinear theory of thin shells -- 3.1. Deformation of a shell -- 3.2. Forces and moments -- 3.3. Equations of equilibrium4. Boundary conditions -- 4.1. Geometry of the boundary -- 4.2. Stresses on the boundary -- 4.3. Static boundary conditions -- 4.4. Deformations of the edge -- 4.5. Equations of Gauss-Codazzi for the boundary5. Soft shells -- 5.1. Deformation of a soft shell -- 5.2. Principal deformations -- 5.3. Membrane forces -- 5.4. Principal membrane forces -- 5.5. Corollaries of the fundamental assumptions -- 5.6. Nets -- 5.7. Equations of motion in general curvilinear coordinates -- 5.8. Governing equations in orthogonal Cartesian coordinates -- 5.9. Governing equations in cylindrical coordinates6. A continuum model of biological tissue -- 6.1. Histomorphology of tissue -- 6.2. A biocomposite as a mechanochemical continuum -- 6.3. Biofactor Zij7. Neurons and neuronal assemblies -- 7.1. The intrinsic regulatory system in the gut -- 7.2. Interstitial cells of Cajal -- 7.3. Electrical activity in neurons -- 7.4. Neuronal circuits8. Chemical synapse -- 8.1. A mathematical model -- 8.2. cAMP-dependent pathway -- 8.3. PLC-dependent pathway -- 8.4. Co-localization and co-transmissionSoft Biological Shells in Bioengineeringintegrates existing experimental data to construct multiscale models of various organs of the human body--the stomach, gravid uterus, urinary bladder, the small and large intestine. These models are used asin silicoplatforms to study intricate physiological and pathophysiological processes and to assess pharmacological modulations on their dynamics. This book is of value to postgraduate students, researchers and medical doctors interested in computational systems biology. Part ofSeries in Physics and Engineering in Medicine and Biology.Students and researchers in the areas of computer science, bioengineering, biology, pharmacology, physiology, and medicine.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Roustem N. Miftahof is a Professor, Dr. of Medicine and Applied Mathematics. Internationally acclaimed as a leading scientist in the fields of computational systems biology and medicine, Professor Miftahof has authored and co-authored six previous books in this field. Nariman R. Akhmadeev works as an Assistant Professor at the Department of Obstetrics and Gynecology at Kazan State Medical University, Russia. With an MD/MBBS degree and a PhD, he combines a career of academician and physician with a specific research interest in the application of mathematical and computational methods to his area.Title from PDF title page (viewed on August 15, 2019).

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Series Title: -
Call Number: -
Publisher: : .,
Collation: 1 online resource (various pagings) :illustrations (chiefly color).
Language: English
ISBN/ISSN: 9780750321952
Classification: 610.28
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): Biomedical engineering.
TECHNOLOGY & ENGINEERING / Biomedical.
Models, Theoretical.
Organs (Anatomy)
Elastic plates and shells.
Tissues.
Elasticity.
Specific Detail Info: -
Statement of Responsibility: Roustem N. Miftahof, Nariman R. Akhmadeev.

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